Publications represent growing interest from scientific community in Novocure’s broadly applicable mechanism of action
ST. HELIER, Jersey–(BUSINESS WIRE)–Novocure (NASDAQ: NVCR) announced today that two independent institutions published scientific research on Tumor Treating Fields (TTFields), representing increasing external interest from the scientific community in Novocure’s innovative, proprietary therapy. The published data support Novocure’s existing body of research establishing TTFields as a low-toxicity, effective cancer treatment while adding new insights to the mechanism of action beyond the known anti-mitotic properties of this modality. The following articles were published:
- Kim et al. “Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation.” Oncotarget, Aug. 19, 2016; Korea Institute of Radiological & Medical Sciences and Department of Bio-Convergence Engineering, Korea University
- Kim et al. “Tumor treating fields inhibit glioblastoma cell migration, invasion and angiogenesis.” Oncotarget, Aug. 18, 2016; Korea Institute of Radiological & Medical Sciences and Department of Bio-Convergence Engineering, Korea University
- Pavesi et al. “Engineering a 3D microfluidic culture platform for tumor-treating field application.” Scientific Reports, May 24, 2016; Singapore–MIT Alliance for Research and Technology, BioSystems
“We have been interested in learning more about Novocure’s treatment with TTFields for some time and were eager to conduct our own research,” said Myonggeun Yoon, a Professor at the School of Biomedical Engineering, Korea University. “TTFields is a promising, novel cancer treatment with broad applicability, and we look forward to seeing how the research on TTFields will evolve.”
“Based on the growing interest in TTFields, we decided to develop a microfluidic system that can be used to rapidly screen the effect of this emerging modality on both cancer and normal cells within an in vivo like microenvironment,” said Dr. Andrea Pavesi, a research scientist from the Singapore–MIT Alliance for Research and Technology (SMART). “Indeed, using our novel device, we were able to demonstrate that TTFields application selectively targeted cancer cells while minimally affecting endothelial cells,” added Dr. Giulia Adriani, also research scientist at SMART.
Internationally, over 20 institutions are studying TTFields, including 10 that are using Novocure’s inovitro system, a lab research tool that allows investigators to efficiently study the effects of different field parameters and TTFields’ synergies with various drug and radiation combinations.
“We are excited that an increasing number of independent institutions are studying TTFields and supplementing the research we have conducted thus far,” said Dr. Eilon Kirson, Chief Science Officer and Head of Research and Development at Novocure. “We believe greater interest in TTFields from the scientific community will help us raise awareness of our innovative cancer therapy.”
Novocure is a commercial-stage oncology company developing a proprietary therapy called Tumor Treating Fields, or TTFields, for the treatment of solid tumor cancers. Headquartered in Jersey, Novocure has U.S. operations in Portsmouth, New Hampshire, Malvern, Pennsylvania, and New York City. Additionally, the company has offices in Germany, Switzerland and Japan, and a research center in Haifa, Israel. For additional information about the company, please visit www.novocure.com or follow us at www.twitter.com/novocure.
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