The science of Tumor Treating Fields has the potential to extend beyond glioblastoma. Treatment with TTFields has shown a consistent antimitotic effect in our preclinical and clinical research over the last 16 years.

We believe we have gained a deep understanding of the underlying mechanism of action and the multiple pathways through which TTFields exert their effects within dividing cancer cells. Our research shows that TTFields can have an anti-mitotic effect in over 15 different solid tumor types in culture and in eight in vivo tumor models, including some of the most aggressive forms of cancer. We are committed to advancing the science of TTFields across a broad spectrum of solid tumors and bringing our treatment to cancer patients who can benefit from our therapy.

Novocure clinical pipeline

as of July 2017

Pre-clinical
Phase II
Phase III
FDA Approved
Recurrent Glioblastoma
Newly Diagnosed Glioblastoma
Brain Metastasis
Non-small Cell Lung Cancer
Ovarian Cancer
Pancreatic Cancer
Mesothelioma
Trial ongoing
Trial complete

we also have pre-clinical data for Tumor Treating Fields in these areas:

Pre-clinical

  • breast cancer
  • cervical cancer
  • colorectal carcinoma
  • gastric adenocarcinoma
  • hepatocellular carcinoma
  • malignant melanoma
  • renal adenocarcinoma
  • urinary transitional cell carcinoma
  • small cell lung cancer
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publications

Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors.

Proceedings of the National Academy of Sciences, Volume 104, No. 24, June 12, 2007.

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NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality

European Journal of Cancer, Volume 48, No. 12, 2012.

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Delayed response and survival from NovoTTF-100A in recurrent GBM.

Medical Oncology, Volume 3, No. 338, January 2013.

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Response assessment of NovoTTF-100A vs best physician’s choice of chemotherapy in recurrent glioblastoma.

Cancer Medicine, Volume 3, No. 3, 2014.

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Characterization and management of dermatologic adverse events with the NovoTTF-100A system, a novel anti-mitotic electric field device for the treatment of recurrent glioblastoma.

Seminars in Oncology, Volume 41, S1 – S14, June, 2014.

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Post hoc analyses of intention-to-treat population in phase III comparison of NovoTTF-100A™ system versus best physician’s choice chemotherapy.

Seminars in Oncology, Volume 41, S25 – S34, October, 2014.

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Response patterns of recurrent glioblastomas treated With Tumor Treating Fields.

Seminars in Oncology, Volume 41, S14 – S24, October, 2014.

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Clinical practice experience with NovoTTF-100A™ system for glioblastoma: the Patient Registry Dataset (PRiDe).

Seminars in Oncology, Volume 41, S4 – S13, October, 2014.

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clinical trials

Novocure continues to test Tumor Treating Fields against a broad range of solid tumor types.

We sponsor clinical trials of Tumor Treating Fields in several cancer types. For more information on our ongoing clinical trials, visit novocuretrial.com and clinicaltrials.gov.

STELLAR

Cancer type: Mesothelioma (Phase 2 pilot)

Protocol number: NCT02397928

About mesothelioma: Malignant mesothelioma is a rare thoracic solid tumor cancer that occurs in approximately 3,000 patients in the United States annually. Asbestos exposure has been strongly associated with the development of mesothelioma, which may occur many years later. Mesothelioma has a very poor prognosis, with a median overall survival of approximately 12 months in most reported studies.

Learn more about STELLAR.

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LUNAR

Cancer type: Non-small cell lung cancer (Phase 3 pivotal)

Protocol number: NCT02973789

About NSCLC: Lung cancer is the most common cause of cancer-related death worldwide, and non-small cell lung cancer accounts for approximately 85% of all lung cancers. Approximately 214,000 new cases of NSCLC are diagnosed in the U.S. each year.

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METIS

Cancer type: Brain metastases from non-small cell lung cancer (Phase 3 pivotal)

Protocol number: NCT02831959

About brain metastases: Metastatic cancer is cancer that has spread from the place where it first started to another place in the body. In metastasis, cancer cells break away from the primary cancer, travel through the blood or lymph system, and form new, metastatic tumors in other parts of the body. The exact incidence of brain metastases is unknown, but it has been estimated that 98,000 to 170,000 new cases are diagnosed in the United States each year. Brain metastases occur in roughly 15% of all cancer patients, and we believe that approximately 40% of brain metastases are a result of NSCLC.

Learn more about METIS.

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additional research

Additional investigator-sponsored trials are also ongoing. For the most up-to-date clinical trial information, including protocol details, please visit the U.S. National Institutes of Health’s website at clinicaltrials.gov.

This information is for medical, and scientific and educational purposes only. TTFields are experimental for the treatment of patients with brain metastases, ovarian carcinoma, pancreatic adenocarcinoma, mesothelioma and non-small cell lung cancer. TTFields has not been approved by the U.S. Food and Drug Administration for commercial use in these indications. Limited by federal law to investigational use only.