New Findings Show TTFields May Be Optimized to Prevent Migration and Invasion of Glioma Cells
ST. HELIER, Jersey–(BUSINESS WIRE)–Novocure™ (NASDAQ: NVCR) will present three preclinical abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2016 to be held April 16-20 in New Orleans. The abstracts highlight the latest understanding of the mechanism of action of Novocure’s novel cancer treatment, Tumor Treating Fields (TTFields).
The AACR is the oldest and largest scientific organization in the world focused on high quality, innovative cancer research.
“We are excited about the newly discovered mechanisms of action of TTFields that will be presented at AACR this year,” said Dr. Eilon Kirson, Chief Science Officer and Head of Research and Development at Novocure. “We believe the possibility to tune TTFields to optimize their effect on glioma invasion and migration may allow personalized treatment optimization for patients with different glioma cell phenotypes in the future.”
Tumor treating fields (TTFields) reduce migration and invasion properties of human glioma cancer cells in vitro (8 a.m. to noon Wednesday, April 20, abstract number: 5078, poster number: 24)
Alternating electric fields (TTFields) induce autophagy in human cancer cell lines (1 to 5 p.m. Tuesday, April 19, abstract number: 3543, poster number: 23)
Tumor-treating fields (TTFields) intensity in the gross tumor volume and peritumoral brain zone: implications for local recurrence in glioblastoma (1 to 5 p.m. Monday, April 18, abstract number: 2051, poster number: 23)
About Tumor Treating Fields Therapy
Tumor Treating Fields (TTFields) therapy is delivered by a portable, non-invasive medical device designed for continuous use by patients. In vitro and in vivo studies have shown that TTFields therapy slows and reverses tumor growth by inhibiting mitosis, the process by which cells divide and replicate. TTFields therapy creates low intensity, alternating electric fields within a tumor that exert physical forces on electrically charged cellular components, preventing the normal mitotic process and causing cancer cell death.
Novocure is a Jersey Isle oncology company pioneering a novel therapy for solid tumors called TTFields. Novocure’s U.S. operations are based in Portsmouth, New Hampshire, and New York City. Additionally, the company has offices in Germany, Switzerland, and Japan and a research center in Haifa, Israel. For additional information about the company, please visit www.novocure.com or follow us at www.twitter.com/novocure.
In the United States, Optune is intended as a treatment for adult patients (22 years of age or older) with histologically-confirmed glioblastoma multiforme (GBM).
In the United States, Optune with temozolomide is indicated for the treatment of adult patients with newly diagnosed, supratentorial glioblastoma following maximal debulking surgery and completion of radiation therapy together with concomitant standard of care chemotherapy.
In the United States, for the treatment of recurrent GBM, Optune is indicated following histologically-or radiologically-confirmed recurrence in the supratentorial region of the brain after receiving chemotherapy. The device is intended to be used as a monotherapy, and is intended as an alternative to standard medical therapy for GBM after surgical and radiation options have been exhausted.
In the European Union, Optune is intended for the treatment of patients with newly diagnosed GBM, after surgery and radiotherapy with adjuvant temozolomide, concomitant to maintenance temozolomide. The treatment is intended for adult patients, 18 years of age or older, and should be started more than four weeks after surgery and radiation therapy with adjuvant temozolomide. Treatment may be given together with maintenance temozolomide and after maintenance temozolomide is stopped.
In the European Union, Optune is also intended for the treatment of patients with recurrent GBM who have progressed after surgery, radiotherapy and temozolomide treatment for their primary disease. The treatment is intended for adult patients, 18 years of age or older, and should be started more than 4 weeks after the latest surgery, radiation therapy or chemotherapy.
Patients should only use Optune under the supervision of a physician properly trained in use of the device. Full prescribing information is available at www.optune.com/safety or by calling toll free 1-855-281-9301 in the US or by email at supportEMEA@novocure.com in the European Union.
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