Combination of Tumor Treating Fields with Standard of Care Therapies, Nab-Paclitaxel and Gemcitabine, Suggests Improved Survival of Patients with Advanced Pancreatic Cancer
Phase 2 pilot PANOVA data presented at the
Progression free survival and one-year survival rate of patients treated with Tumor Treating Fields plus nab-paclitaxel and gemcitabine were more than double those of nab-paclitaxel and gemcitabine-treated historical controls
ST. HELIER, Jersey–(BUSINESS WIRE)–
The PANOVA trial was a prospective, single-arm study testing the feasibility, safety and preliminary efficacy of Tumor Treating Fields (TTFields) in patients with advanced pancreatic cancer whose tumors could not be removed surgically and who had not received chemotherapy or radiation therapy prior to the clinical trial. The second cohort included 20 patients who received a combination treatment regimen of TTFields plus nab-paclitaxel and gemcitabine.
Median progression free survival in the TTFields-treated group was 12.7 months (compared to 5.5 months in nab-paclitaxel plus gemcitabine historical controls) and median overall survival was not yet reached. The median overall survival was not reached and the one-year survival rate was 72 percent (compared to 35 percent in nab-paclitaxel plus gemcitabine historical controls). Forty percent of the evaluable tumors had partial responses (compared to 23 percent with nab-paclitaxel plus gemcitabine alone) and another 47 percent had stable disease (compared to 27 percent with nab-paclitaxel plus gemcitabine alone). Patients reported no serious adverse events related to TTFields.
“Pancreatic cancer kills more than 300,000 individuals each year worldwide. As the vast majority of pancreatic cancer cases are diagnosed during the late stages, patients with advanced disease are in dire need of additional treatment options,” said Dr.
“We are extremely pleased with these results,” said Dr.
TTFields are not approved for the treatment of pancreatic cancer by the
About Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death in the U.S.
Headquartered in Jersey,
In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocure’s current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as “anticipate,” “estimate,” “expect,” “project,” “intend,” “plan,” “believe” or other words and terms of similar meaning. Novocure’s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, regulatory and political conditions as well as more specific risks and uncertainties facing
Media and Investor Contact:
Ashley Cordova, 212-767-7558