NovoTTF Therapy is delivered using non-invasive, insulated transducer arrays that are placed directly on the skin in the region surrounding the tumor. NovoTTF Therapy is unlike previous applications of electricity in medicine. Specifically, NovoTTF Therapy does not deliver any electric current to the tissue. NovoTTF Therapy does not stimulate nerves or muscles or heat tissue. NovoTTF Therapy creates an artificial, alternating electric field within the tumor that attracts and repels the charged components of the cells during mitosis. The forces that the alternating electric fields exert on the cellular components are shown to inhibit mitosis and induce cell death prior to division in preclinical models.
NovoTTF Therapy is designed for continuous use throughout the day by the patient. The delivery systems are designed to allow patients to maintain their normal daily routine while treating their disease. The video on this page shows the NovoTTF delivery systems for glioblastoma patients and lung cancer patients, Novocure’s most advanced clinical programs. Patients undergoing NovoTTF Therapy generally report a slight warming sensation at the transducer array site. Skin irritation at the transducer array site has been the only clearly device-related adverse event reported during clinical trials of NovoTTF Therapy.