TTFields are low intensity, intermediate frequency, alternating electric fields that disrupt mitosis and cytokinesis. TTFields exert physical force on charged cellular components that is sufficient to stop normal cell division processes, specifically the formation of the mitotic spindle from tubulin dimer proteins. TTFields also exert a physical force on other components of the cell during division, a force which is sufficient to cause cell death prior to division.

Mechanism of Action

Tumor Treating Fields, or TTFields, are low intensity alternating electric fields that work within the frequency range of 100-300 kHz. TTFields...

Delivery Method

TTFields therapy is delivered using non-invasive, insulated transducer arrays that are placed directly on the skin in the region surrounding the tumor.

Delivered by Investis (opens in a new window)